The risk of permanent disability or death from the MMR vaccine may be greater than the risk posed by measles, mumps or rubella infection because large enough vaccine safety studies haven't been done, according to a collection of new documents released by Physicians for Informed Consent (PIC).
The collection includes disease information statements for measles, mumps and rubella, and a vaccine risk statement for the MMR vaccine.
According to the Mayo Clinic, measles is a viral infection typically accompanied by a skin rash, fever, cough, runny nose, sore throat, inflamed eyes and tiny white spots on the inner cheek.
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Mumps and rubella also are viral infections. According to PIC, all three viral infections typically resolve on their own with proper rest and hydration in almost all cases.
Dr. Shira Miller, PIC's founder and president, told The Defender, "The main takeaway is that the MMR vaccine has not been proven safer than measles, mumps and rubella."
PIC is a nonprofit that delivers data to doctors and the public so they can "evaluate the data on infectious diseases and vaccines objectively, and voluntarily engage in informed decision-making about vaccination."
Miller explained that the MMR vaccine clinical trials didn't include enough subjects to be able to prove that the risk of permanent disability or death from the vaccine is less than the risk of permanent disability or death from measles, mumps or rubella.
The number of measles, mumps or rubella infections that result in permanent disability or death is so low that researchers would need to have at least 50,000 subjects in a clinical trial to be able to show that the vaccine is safer than the disease.
The MMR vaccine's clinical trials fall very short of that benchmark, according to PIC's statement on MMR vaccine risk.
Prelicensure clinical trials for vaccines, including the MMR shot, are "relatively small and usually last no longer than a few years," according to the Centers for Disease Control and Prevention's (CDC) 2024 "Manual for the Surveillance of Vaccine-Preventable Diseases."
The 2024 edition of the CDC manual doesn't specify exactly how many subjects are in these "relatively small" trials. However, the 2011 edition stated that "relatively small" meant that such trials are "usually limited to a few thousand subjects."
The rate of disability or death among healthy children from any of those three diseases is incredibly rare. PIC wrote:
"For children under age 10 at normal risk (i.e., with normal levels of vitamin A and infected after birth), the pre-vaccine annual risk of death or permanent disability from measles, mumps, and rubella respectively was 1 in 1 million, 1 in 1.6 million, and 1 in 2.1 million. ...
"Therefore, the cumulative annual risk of a fatal or permanently disabling case of any of those diseases was about 1 in 500,000, and the risk over a 10-year span was 1 in 50,000."
In other words, clinical trials would need at least 50,000 subjects to detect one case of death or disability from a measles, mumps or rubella infection.
Meanwhile, no safety studies on the MMR vaccine have been done that looked for possible genetic mutations, impaired fertility or cancer, according to the product's package insert.